Experimental Study Of Acute Hemorrhagic Necrotizing Pancreatitis Complicated With Lung Injury

Backgrounds and aims:Acute hemorrhagic necrotiting pancreatitis (AHNP) is one of the common surgical acute abdomen in General Surgery. It is featured by an urgent onset, speedy progress, high death rate and etc. Pancrea damages and extrapancreatic organ damages were found in patients. Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) were one of the most common early complications. Researches showed that approximately 60 percent of patients with AHNP who died within a week were accompanied with lung injury or ARDS In recent years, although many scholars have done lots of researches on the mechanism of pancreatitis associated with lung injury, it's not yet been clarified. Therefore, it has become an urgent necessity for the clinics to clarify the mechanism of AP associated with lung injury and reduce the death rate of patients suffering from acute pancreatitis associated lung injury(APALI). As a result, we established AHNP models of rats in this experiment so that we could illustrate the mechanism of AHNP associated lung injury through the dynamic observation of inflammatory factors and the expression of Caspase-3 in lungs in this model. Methods:A total of 80 male Wistar rats were randomized equally into acute hemorrhagic necrotiting pancreatitis group (AHNP Group, n=40) and control group (Control Group, n=40). The model of AHNP was established by 1 ml injection of 5% sodium taurocholate into the pancreatic capsule of the rats in AHNP Group. Conctrol Group were only operated with a celiotomy. 10 rats from...