The Study Of The Relevance Between Chinese Medicine Syndrome Of MCI And The ApoE Gene's Polymorphism

In order to discuss the relevance between syndrome of TCM about mild cognitive impairment (MCI) and the ApoE gene's polymorphism, based on my tutor's long-term clinical practice, syndrome differentiation of TCM and all literature of previous dynasties, we propose the theory that the main pathogenesis of MCI is deficiency of kidney and consumption of sui. And combined modern theory of ApoE gene's polymorphism and its relationship with MCI, a clinical observation was carried on. It included 210 patients of MCI, and the syndromes of MCI were 7 types as follows: deficiency of kidney and consumption of sui, phlegm coating clear qiao, stasis in the luo, heat-drug overabundance, ascending hyperactivity of liver yang, stagnation of internal organs and remaining of muddy and deficiency of qi and blood (30 examples in each type of syndrome), while 30 people were also chosen as the examples of normal contrast in each type. The PCR-RFLP method was adopted to appraise the ApoE genotype in each group's distributed situation. Finally shows:ε4 allele was the dangerous factor of MCI whileε3 allele was the protection factor of MCI. Compared with normal control group,ε4 allele could increase the danger of all types of MCI syndrome except the type of stagnation of internal organs and remaining of muddy; and the type of deficiency of kidney and consumption of sui had obvious relevance withε4. So that we can confirm the objective standard for syndrome of TCM about MCI from the genetics angle and the gene level, provide the scientific basis for the objectification of diagnosis of Chinese medicine syndrome and offer the research thoughts and basis for intervention of dangerous factors of TCM and treatment based on syndrome differentiation of MCI.