Study Of The Expression Of Survivin And Ki67 In Cervical Intraepithelial Neoplasia And Cervical Carcinoma

Objective: Cervical carcinoma is one of the most common malignant carcinoma in female reproductive tract. It is a long process from pre-malignant cervix to cervical carcinoma. The occurrence of tumor not only correlates with the cell proliferation and differentiation but also with the change of apoptosis gene. If the relation of proliferation and apoptosis is out of balance, that will result in the occurrence of tumor. Survivin is a new inhibitor apoptosis protein. Researches reveal that survivin can inhibit apoptosis and promote proliferation. Ki67 is a useful index for cell proliferation. This experiment is to investigate the expression of Survivin and Ki67 in cervical intraepithelial neoplasia and cervical carcinoma, and explore the relationship between significance of proliferation and apoptosis in cervical intraepithelial neoplasia and cervical carcinoma, their role in the pathogenesis of cervical carcinoma and the possibility of being biomarkers for early detection.Methods: The expressions of Survivin and Ki67 protein were evaluated in 70CIN(including 26CIN â… , 21CINâ…¡, 23CINâ…¢)and 22 cervical squamous cell carcinoma by immunohistochemistry(SABC method). 14 normal cervix tissue were taken as control.Results: (1) The positive rate of Survivin in CIN â…  , CINâ…¡, CINâ…¢, cervical squamous cell carcinoma and normal cervix tissue was23.08...