A Preliminary Study On The Prognostic Value Of Cardiac Tropinin T For In-Hospital Death In Patients With Acutely Exacerbated Chronic Obstructive Pulmonary Disease

OBSTRUCTIVES 1.To investigate the incidence of cardiac troponin T (cTnT, a specific marker for cardiac injury) elevation and the correlation between cTnT and PaO₂ in parients with acutely exacerbated chronic obstructive pulmonary disease. 2. To assess the prognostic value of cTnT elevation during hospital stay for acute exacerbation of chronic obstructive pulmonary disease.METHODS Eighty-two consecutive patients with confirmed acute exacerbation of chronic obstructive pulmonary disease were enrolled in this prospective study. Serum cTnT, myoglobin (Mb), creatine kinase -MB mass (CK-MBmass) and arterial blood gas were measured within 24 hours after admission and 24h later (in patients with no improvement of respiratory failure and the degree of dyspnea), and twelve-lead electrocardiogram was taked in the same time. The following data were collected: general data ( gender, age ) , body mass index, MMRC dyspnea scale, vital sign, risk factors for atherosclerotic artery disease (active smoking, hypertension, diabetes mellitus, hyperlipidemia) , white blood cell count, ventricular arhythmia, atrial fibrillation, clinical presence of right ventricular dysfunction. The levels of cTnT, Mb and CK-MBmass above the upper limit of normal value were considered elevated. The time of admission was regarded as zero point, then follow-up clinic outcome...