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Psychological Evaluation Of Cognitive Function And ~1H-MRS Study Of Frontal Lobe And Hippocampus Metabolism Among Obese Adolescents

Posted on:2007-07-07Degree:MasterType:Thesis
Country:ChinaCandidate:Y SunFull Text:PDF
GTID:2144360185979225Subject:Child and Adolescent Health and Maternal and Child Health Science
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Objectives The study aims to explore reasoning and intellective capacity in obeseadolescents and to provide scientific basis for the prevention and treatment on child obesity. And determine variation characteristics of attention ability in obese adolescents by giving mental workload. To find whether obese adolescents had neuro-chemical abnormalities in frontal lobe and hippocampus.Methods The intellectual and deduction characteristics of 82 obese adolescents andadolescents, aged 12 to 18 years, were compared to those of 82 normal-weight adolescents and adolescents of the same age group, utilizing Raven's Standard Progressive Matrices ( R' SPM) and four subtests of Wechsler Intelligence Scale for Adolescents-Chinese revision (C-WISC). Adolescents of the two groups were paired according to age groups, height, schooling level and parental educational level. Average scores of all indices were calculated and compared between the two groups. Mental workload was manipulated by presenting subjects with five tests, including Raven's Standard Progressive Matrices (R' SPM) and four subtests of Wechsler Intelligence Scale for Children-Chinese revision (C-WISC) in 60 to 70 minutes. Reading velocity, mistake rate, index of mental capacity (IMC) in Number Cancellation Test and test time, the right number of tracking lines in Visual Tracking Test were calculated and compared between the two groups. Anthropometric indicators were measured in all participants. Intelligence quotients (IQs) were assessed by using Raven's Standard Progressive Matrices (R' SPM). Proton magnetic resonance scans (~1H-MRS) were performed in 8 obese adolescents and 8 non - obese adolescents as control. Spectral peaks of N-acetylaspartate (NAA), Creatine (Cr), Choline (Cho) of two cortexes were measured and their ratios were computed and compared.
Keywords/Search Tags:Obesity, Adolescents, Intelligence, Intelligence Test, Attention, Body composition, Magnetic Resonance Spectroscopy
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