Study On Shh And PTCH Expression In Esophageal Squamous Carcinoma

ObjectiveEsophageal cancer is the 6th most frequent cause of cancer death worldwide. In China, the mobility is fairly high, especially esophageal squamous cell carcinoma (ESCC). Most of the patients with esophageal cancer were found in late stage, because their early symptom didn't manifest. The five-year survival rate was only about 25% after ablation. Bu, if resection in early stage, the five-year survival rate elevates to 90%, and the ten-year survival rate is around 73%. Approaching the pathogenesis of esophageal cancer and searching the biomarker for early detection and early diagnosis become one of the main directions of the scientific research at present. Recently, many scientists had made painstaking effort to look for the mechanism of esophageal cancer, thereby, we can realize the diagnosis and treatment in early stage. But the etiology and pathogenesis is still in nubilous up to now. So it would be a gigantic mission to continue the research on esophageal carcinoma. The hedgehog pathway plays a critical role in the development of the foregut. Recent studies indicate that the hedgehog pathway activation occurs in the pancreas stomach, colon and other gastrointestinal cancers. However, the role of the hedgehog pathway in primary esophageal cancers is not well studied. Here, we would detect the expression of hedgehog pathway components SHH and PTCH in esophageal...