Effects Of Tang Xin Kang On NF-κB Of Diabetic Cardiomyopathy Rats

Obective: To evaluate the therapeutic effects of Tangxinkang on diabetic cardiomyopathy and discuss its mechanism .Methods: In this experiment, the model rats were established by STZ and hyper-calorie diet. We studied the model in glucose metabolism, insulin , myocardium histomorphology and nuclear factor-kappaB and we also discuss the curative mechanism in biology of Tangxinkang treating the diabetic myocardial damage.Results: The results show that: (1) Tang xinkang has good effects on decreasing glucose and hbalc in blood and increasing the level of insulin.(2)Tangxinkang has good repaired effect on damaged cardiac muscle and pancrease in histomorphology change. (3 )Tangxinkang has obvious adjustment role on over-expressed nuclear factor-kappaB of diabetic cardiac muscle (P<0.01) .Conclusion: Tangxinkang has an obvious therapeutic role on diabetic cardiomyopathy through adjust the over-expressed nuclear factor-kappaB of diabetic cardiac muscle mainly.