Expression And Relation Of Matrix Metalloproteinase And Angiopoietin In Pituitary Adenomas

Objective: Pituitary adenomas are generally benign intracal tumor,They have been reported to represent 10%-20% of the whole intracal tumors.Pituitary adenomas often grow limitedly, but part of them invade into the local brain tissues,such as blood vessels,cavernous sinus,saddle sclerotin and so on.Radical surgical treatment of the invasive pituitary adenommas is more difficult than those of non-invasive tumors.After the operation,most of the patients must undergo radio-therapy and so on.But,they often recur with in a short period after operation.It is still a tough problem for neurosurgeon to cure pituitary adenomas.Many study indicate that growth and metabolism of entity tumor must depend on their own blood vessel.New vessels are closely relate to the growth, infiltrate and metastasis of tumors. Tumors and his interstitial vessels are interdependent:Tumor cells secret a series of angiogenesis factor and inhibitory factor of angiogenesis that regulate the growth of tumorous blood vessel, and the tumorous blood vessel promote the growth and in-vasion of tumor.Angiopoietin (Ang) familial important member:Ang-1,Ang-2,they play an important role in the processes of angiogenesis.In addition, invasion to adjacent...