The Accordance Between The CT Appearance And Traditional Chinese Medicine Syndrome Types For Advanced Stage Peripheral Pulmonary Carcinoma: A Preliminary Clinical Observation

PURPOSE: To observe the accordance between the CT appearance and Traditional Chinese Medicine (TCM) syndrome types for advanced stage Peripheral Pulmonary Carcinoma (PPC), and provide the objective diagnostic evidence of peripheral lung cancer for Traditional Chinese Medicine syndrome types.MATERIALS AND METHODS: From Mar. 2004 to Jan. 2006, 94 cases with PPC determined by pathology and imaging examination in the first affiliated Hospital of Guangzhou University of TCM were typed according to four syndrome differentiation. 31 was in phlegm and stasis due to stagnation of lung syndrome group, 27 in superabundance of dampness and phlegm due to spleen-asthenia syndrome group, 23 in phlegm and disturbance of heat due to yin-deficiency syndrome group, and 13 in deficiency of both qi and yin syndrome group. About 24 CT appearances such as vacuole sign, pleural effusion, vascular bundling, and pleural indentation were the variables of the study. CT scanning of the thorax, abdomen and brain were taken for all the patients. The accordance between the CT appearance and TCM syndrome types for advanced stage PPC was analyzed. The SPSS 10.0 statistic software was applied in the study.RESULTS: There is accordance between deficiency of both qi and yin syndrome and the T, N stages and sex. The OR value of sex, T stage and N stage are respectively 8.572, 2.633 and 11.993. The Logistic forecast equation isP=1/[1+e^{(-6.310+2.148sex+0.968T+2.484M)}]. The acuity of equation is 39. 13%. Theeigenvalue of equation is 83.1%.There is accordance between phlegm and disturbance of heat due to yin-deficiency syndrome and lobulation sign. The lobulation sign was more common in phlegm and disturbance of heat due to yin-deficiency syndrome group. The OR value of lobulation sign is 3.315. TheLogistic forecast equation is P=l/Ll+e J. The eigenvalue ofequation is 44.64%. The vacuole sign, pleural effusion, T, M stages is the discriminative variable about superabundance of dampness and phlegm due to spleen-asthenia syndrome. The OR value of vacuole sign, pleural effusion, T stage and M stage are respectively 6. 315, 8.149, 2. 187 and 2. 901. The Logistic forecast equation is P=l/[l + e" ^6-658+1.843V+2.098PE+0.782T+i.605N) L The acu.tyof equation is 74. 07%. The eigenvalue of equation is 74. 63%. There is accordance between phlegm and stasis due to stagnation of lung syndrome and vascular bundling, pleural indentation. The vascular bundling and pleural indentation were more common in phlegm and stasis due to stagnation of lung syndrome group. The OR value of vascular bundling, pleural indentation and vascular bundling*pleural indentation are respectively 3.920, 3.255 and 10. 133. The- (-1.999 +3. 920PI+3. 255VB ) Logistic forecast equation is P=l/[1 + e ]. Theeigenvalue of equation is 60. 34%.CONCLUSIONS: There are accordance between the Traditional Chinese Medicine types and the CT appearance of advanced stage PPC. The CT appearance of primary PPC may be considered the objective evidence for syndrome types of TCM, which are contributed to determine selecting treatment and therapeutic effect. It is necessary to further study the mechanism between the CT appearance and the syndrome types of TCM.