Clinical Study On BuShenChangDuZhiLiu Decoction In The Treatment Of Ankylosing Spndylitis

ObjectiveTo assessed the clinical effectiveness and safety of BuShenChangDuZhiLiu decoction that is empirical decoction of Jiao Shude in the treatment of AS patients that is renal deficiency and cold syndrome. MethodOverall, 30 patients with active AS were treated with BuShenChangDuZhiLiu decoction daily. The clinical response was assessed by standardized parameters. Assessment on Ankylosing Spondylitis Response Criteria ASAS, TCM symptom effect, Main index effect, Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP),Blood routine, Liver and Kidney function of AS patients were analyzed after 24 weeks of treatment. The adverse effect was recorded. Result(1)There was apparente improvement according to the Assessment in Ankylosing Spondylitis (ASAS) criteria after treatment . The improvement rate of ASAS20, ASAS50 and ASAS70 is 36. 67%(11/30), 40. 00%(12/30) and 3.33%(l/30) respectively after 12 weeks of treatment. And it is respectively 10.0%(3/30), 66. 67%(20/30) and 10.00%(3/30) after 24 weeks. (2)The total effective rate of TCM symptom effect in the control patients was 46. 67%(14/30), 86. 67%(26/30) and 93. 33%(28/30) respectively after 4, 12 and 24 weeks of treatment. (3)There was significant difference in 10cm VAS for back pain, duration of back early morning stiffness(EMS), Bath Ankylosing Spondylitis Disease Activity Index(BADAI), global assessment of patients and doctors after 4 weeks of treatment in contrast to pretreatment (P<0. 05). While there was no significant difference in Bath Ankylosing Spondylitis Functional Index(BASFI) after 4 weeks of treatment in contrast to pretreatment P>0. 05).And there was significant difference in main index effect (10cm VASfor back pain, EMS, BASFI, BADAI,global assessment of patients and doctors) after 8, 12 and 24 weeks of treatment in contrast to pretreatment (KO. 05). In addition, 63.33% (19/30) of the patients showed a more 50% improvement according to the BASDAI after 24 weeks of treatment. In the Schober' s test, occiput to wall and finger to floor distance, there was significant difference after 24 weeks of treatment in contrast pretreatment (R0. 05). While the difference'of chest expension was not significant (P>0. 05). (4)There was significant difference in ESR , CRP after 24 weeks of treatment in contrast to pretreatment (K0. 05). (5)There was no significant difference in Liver function and Kidney function after 24 weeks of treatment in contrast to pretreatment. There was not obviously dysfunction during an observation period of 24 weeks. ConclusionAccording to the data provided here medical treatment with BuShenChang-DuZhiLiu decoction seems to be effective and safe during an observation period of 24 weeks. Drug tolerance was good. None led to discontinuation of treatment.