Expression Of Skp2 And Its Correlationwith PTEN In Tumors Of Larynx

Objective: To study the expression of Skp2, PTEN in human laryngeal tumors, to explore their relations and clinical significance. Methods: Formalin-fixed and paraffin-embedded tissues from 79 cases of laryngeal carcinoma, 16 cases of atypical hyperplasia of vocal fold, 14 cases of adult laryngeal papillomas and 27 cases of vocal cord polyp were evaluated for the expression of Skp2, PTEN by SP immunohistochemistry, the levels of these proteins in tissues with the different types of lesion and their correlation with clinicopathological parameters of laryngeal carcinoma were analyzed. Results: The expression rates of Skp2 protein in vocal cord polyp,adult laryngeal papillomas ,atypical hyperplasia of vocal cord and laryngeal carcinoma were 11. 11%, 14. 29%, 37.50% , 39. 24% respectively and had an increasing trend. There aws significant defference among them(p<0.01); The expression rates of PTEN protein in vocal cord polyp, adult laryngeal papillomas , atypical hyperplasia of vocal cord and laryngeal carcinoma were 100%, 92. 86%, 75. 00%, 56.96% respectively and had an descending trend. There was significant defference among them(p<0.05); The positive expression of Skp2 protein in laryngeal carcinoma was related to differentiation, lymph nodal metastases and prognosis(p<0. 05), but no association with clinical T stage , sex ,age and location(p>0.05).The expression of PTEN in laryngeal carcinoma was associated with clinical T stage, lymph nodal metastases, differentiation and prognosis(p<0.05), but there was no associated with sex, age and location(p>0. 05). The positive expression of Skp2 protein with negative expression of PTEN protein in laryngeal carcinoma was related to lymph nodal metastases and prognosis(p<0. 05), but no association with clinical...