Evidence-based Evaluation And Clinical Application Of Human Heart-type Fatty Acid-binding Protein In Early Diagnosis Of Acute Myocardial Infarction

Background:Among the diseases of acute coronary syndrome(ACS), acute myocardial infarction(AMI) is a severe one which will cause exhaustion of the left ventricle and pump failure if not treated in time. Therefore, the early diagnosis of AMI is very important for improving the prognosis of AMI patients.As is known for all, cardiac markers play a very important part in early diagnosing AMI for their sensitivity and objectivity in myocardial necrosis. However, no one acts well both in sensitivity and specificity among the cardiac markers used now in clinic. The evidence achieved recently reveals that the heart-type fatty acid-binding protein(H-FABP) may do a better job in early diagnosing AMI.H-FABP is a small protein which has low molecular weight and exists specifically in the cardiac muscle. The metabolism research shows that H-FABP can arrive into the blood early after AMI and can be detected in the serum sample. What's more, the new assay methods developed recently have achieved a higher detective sensitivity and a shoter assay time, which increases the feasibility of the clinical use of H-FABP in early diagnosing AMI.