Value Of H-FABP Combined With BNP On The Evaluation Of Early Cardiac Function With Acute Myocardial Infarction

Objective:To study the value of heart-type fatty acid binding protein(H-FABP)combined with brain natriuretic peptide(BNP)on the evaluation of early cardiac function in patients with acute myocardial infarction(AMI).Methods : A total of 58 patients with acute myocardial infarction treated in Department of Emergency,The First People’s Hospital of Xiangtan City were selected from March to December 2018 as research group,and 21 healthy people who had been to the physical examination center of the same hospital during the same period were selected as control group.Selected Criteria: No limit in gender;30 to 80 years old;Research Group: AMI patients with blood pressure lower than 160/100 mmHg determinated H-FABP,BNP and cardiac troponin I(cTnI)through venous blood,completed 12 and 18 leads electrocardiogram and ultrasound cardiogram,conducted Killip cardiac functional grading,and measured Left Ventricular Ejection Fraction(LVEF),maximum value of mitral E-peak flow velocity(E),maximum value of mitral A-peak flow velocity(A)and calculated E/A during the initial 24 hours after the onset of disease in hospital;Control Group: The people with blood pressure lower than140/90 mmHg who were previous healthy without cardiovascular,cerebrovascular and pulmonary diseases,determinated H-FABP,BNP,cTnI through venous blood on an empty stomach,completed ultrasound cardiogram and measured LVEF after admission.The research group wasdivided into 1-4 groups according to Killip cardiac functional grading,and divided into group E/A>1 and group E/A≤1 according to E/A.Compare the differences between research group and control group in age,gender,plasma H-FABP,BNP,cTnI levels and LVEF by statistical methods;compare the differences of plasma H-FABP,BNP and cTnI in KillipI-IV(group 1-4)respectively in study group;compare the differences of plasma H-FABP,BNP,cTnI and LVEF in E/A respectively in study group;analyze the correlation between plasma H-FABP,BNP,cTnI and LVEF respectively;compare the value of H-FABP combined with BNP,H-FABP combined with cTnI and BNP combined with cTnI on the evaluation of early cardiac function in patients with acute myocardial infarction.Results: In research group,plasma H-FABP,BNP and cTnI levels were significantly higher,while LVEF levels were significantly lower than those in control group,with statistically significant differences(p < 0.05).Plasma H-FABP,BNP and cTnI levels were increased with the increasing Killip cardiac function classification(p < 0.05).In group E/A≤1,LVEF was lower than group E/A>1(p<0.05),while the plasma H-FABP,BNP and cTnI levels were higher than group E/A>1 in research group(p<0.05).Plasma H-FABP,BNP and cTnI levels were negatively correlated with LVEF levels respectively(r=-0.738,r=-0.782,r=-0.507,p < 0.05).The sensitivities of H-FABP combined with BNP,H-FABP combined with cTnI and BNP combined with cTnI on the evaluation of early cardiac function in AMI patients were 89.66%,86.21% and 74.14%,respectively,while the specificities were all 100%.The AUC of ROC in H-FABP combined with BNP,H-FABP combined with cTnI and BNP combined with cTnI were0.961,0.953 and 0.914 on the evaluation of early cardiac function in AMI patients.Conclusion:Compared with H-FABP combined with cTnI and BNPcombined with cTnI,H-FABP combined with BNP has the highest value on the evaluation of early cardiac function in AMI patients.