| BackgroundExisting abundantly in atherosclerotic plaque, the tissue factor (TF) plays a critical activating role in the rupturing of plaque and the occurrence and development of thrombosis in the patient with acute coronary syndrome. The component of atherosclerotic plaque determined its stability. The instable plaque was of thin fiber wall and rich in vast lipoids and inflammatory cells. When stimulated by inflammatory medium, the monocyte, macrophage and lymphocyte permeating into the plaque expressed vast TF to increase the TF content in instable plaque and thus make the plaque rupture easily. The ruptured plaque formed thrombus to induce complete or incomplete obstruction of coronary artery and thus cause its acute events. The influencing on expression and function of plaque TF has become new target point of anti-thrombus therapy. Type II diabetes mellitus (T2DM) is a disease seriously influencing human life and health, and its death is primarily caused by large blood vessel complications. The basic pathological change of large blood vessel complications in T2DM is atherosclerosis mainly involving blood lipid/fibrinolysis system disorder, vascular endothelial injury, and abnormal TF expression.Atorvastatin is a clinically common lipid-lowering drug. As shown by a large... |
PDF Full Text Request