Research Of The Expression Of The SYK Gene In Human Colonic Carcinoma

Background:Spleen Tyrosine (Y) Kinase (Syk) is a protein-tyrosine kinase whose expression has been found in various cells such as the hematopoietic,lymphocyte,fibroblast and vascular endothelial cells. Human Spleen Tyrosine (Y) Kinase (Syk)locus was mapped to be chromosome 9 at band q22,made up of 629 amino acids, molecular weighted 72KD.Syk gene is considered as a candidate anti-oncogene.Syk expression in colonic carcinoma was not reported.Objective:To evaluate the effects of the Syk gene expression in human colonic carcinoma on tumor growth and metastasis.Methods:The expression of Syk gene in the 40 fresh freezed tissues of colonic carcinoma patients(tumor tissues,adjacent normal tissues)was detected by RT-PCR technique.ResuIts:All nomal colonic tissues were detected the expression of the Syk gene.Compare to nomal tissues,27out of40 colonic carcinoma did not show any detectable Syk expression.And there were...