Expression Of Ang-2, MMPs And ERK Protein On The Colonic Carcinoma And Its Clinicopathological Significance

Objective: To investigate the expression of Ang-2, MMPs and ERK protein on the ulcerative colitis and colon adenoma and colonic carcinoma, and its correlation with the clinicopathological parameters of colonic carcinoma. To investigate the clinical significance of Ang-2 and MMPs and ERK protein in the pathogenesis course of colonic carcinoma and its roles in the angiogenesis of colonic carcinoma. Method: Ang-2 and MMP-2 and MMP-9 and ERK-1 and ERK-2 and VEGF and CD34 relative antigentic protein expression were measured by immunohistochemistry in resection specimens from 31 colonic carcinoma patients, 20 ulcerative colitis and 21 colon adenoma and 10 normal colon tissues served as controls, and its clinicopathologic relation were analysised by SPSS 10.0 for Windows software. Results: The positive rate of Ang-2 and MMPs and ERK protein expression in colonic carcinoma was higher than that in normal colon tissues (P<0.05) , its expression positive rate had significant discrepancy and increased between ulcerative colitis, colon adenoma and to colonic carcinoma. The positive rate of Ang-2 and MMPs and ERK protein expression were significantly correlated to the clinicopathologic parameters such as the Dukes'stage and the lymph nodes metastasis or not of colonic carcinoma (P<0.05 ) . The positive rate of VEGF protein expression and the MVD counting in colonic carcinoma were higher than...