Study Sorbaria Sorbifolia Against DMN Induced Chronic Liver Damage In Rats

Objective: To study Sorbaria sorbifolia (SSE) against DMN-induced chronic liver Damage in rats.Methods: Seventy-two rats were divided into four groups, SSE and colchicinwere given orally. Serum Hyaluronic(HA) and type precollagen(PCIII) were detected by radioimmunoassay. Degrees of fibrosis and a-smooth muscle actin(a-SMA) were determined by histopathology under microscope. Hydroxyproline(Hyp) and the markers of liver function were examined also.Results: The levels of serum ALT, AST, ALb, AKP in SSE groups were notablyimproved as compared with the model group. Serum HA, PCIII and Hyp of hepatic tissue in SSE groups were obviously lower than those of model group. The markers of oxidative stress (SOD, MDA, GSH-Px) were strikingly improved also in SSE groups. HE stains and a-SMA expression showed that the degrees of liver fibrosis in SSE group was slight than that of model group. There was significant difference between the model group and SSE groups (P<0.05 or P<0.01) . The rats in SSE groups were better than those of colchinicines group.Conclusions: SSE is able to protect against carbon tetrachloride-induced chronic liver damage, which may act through oxidative stress.