The Protective Effects Of Magnesium Sulfate On Vascular Dementia In Rats

Background and ObjectiveVascular dementia (VD) is an acquired impairment of cognitive function that caused by cerebral vascular diseases, mainly relate to the ischemic cerebrovascular diseases. With the aging population of the world, the incidence of vascular dementia rises year by year. It has already been a clinical difficult problem to threaten the health of mankind, especially the aged people. How can we take measures to reduce neuron death, protect the nerve cells, mitigate the intellectual obstacle after being ischemic have already become one of the focuses of current research.A large amount of studies have proved that the metabolism of Mg²⁺ in vascular dementia patients is abnormal. As one of the neuron pharmaceutical protection, magnesium sulfate (MgSO₄) can block or mitigate the damage to the neurons through various methods, produce cooperative effect to dementia with other medicines. But it still needs to make a thorough study about the concentration of the pharmaceutical treatment of magnesium and precise function mechanism, etc. Animal's experiments verify: The death forms of neurons of brain injury relate to the severity and duration of the ischemia and anoxia. The acute death of neurons of brain relies mainly on necrosis, while delayed death relies mainly on apoptosis. Neuronal nitric oxide synthase (nNOS) can accelerate the production of the nitric oxide (NO) when there is ischemic in the brain. This kind of NO can do toxic to the nerve cells. Someone has...