The Relation Between Transforming Growth Factor Beta-1 Gene Polymorphisms And Coal Worker Pneumoconiosis

At present, the pneumoconiosis is one of the most risk occupational diseases in our country. According to the statistics, 2/3 of all occupational diseases in China are the pneumoconiosis, so the prevention and therapy of this disease is very important, however the mechanism of it is complicated and hard to explain.So the key to control is to prevent. It is an important precautionary measure to detect the high-risk group and confine them to engaged in dust work.As domestic and interenational reported , cytokines played important roles in the formation of pneumoconiosis .Transforming growth factorβ1 (TGF-β1 ) was especially paid attention on . TGF-β1 can participate the fibrosis course of pneumoconiosis by regulate collagen ,FN,MMP et al. The concentrations of TGFB in plasma had been correlated with the development of several diseases. Of the known polymorphisms, only the C-509T polymorphism in the TGFβ1 promoter had been shown to be significantly associated with the plasma concentrations of TGF beta 1 .So the the study was designed. To approach the effect of TGF-β1 gene polymorphisms on...