The Function Research Of Specific APLs On Psoriasis-form Lesions In Animal Model

Psoriasis is a chronic inflammatory dermatological disease with high incidence rate, easy repetition and difficulty in treatment. The major characteristics of psoriasis is the keratinocyte(KC) propagates excessively. Although the pathogenesis of the disease has not been definitively understood, three key factors are a certain genetic background, infection and cellular immunity disorder with T-cell playing the key role. Keratin is a main component of intermediate filaments. As a major structure element of epithelial cells in cytoskeletons, keratin is recognized as a maker protein of epithelial cells. Keratin 17 (CKRT17—K17) is the type-1 keratin. It is highly expressed in psoriatic lesions. In normal epidermis, its expression is detected in hair follicles of growth phase and sweat glands. Studies show that, CKRT17 shares a similar antigenic epitope with M protein in streptococcus. Both CKRT17 and M protein possess several T-activating sites, through which, the T-cell can be activated and promoting the release of Interferon γ (IFN- γ ). IFN- γ can also increase the expression of CKRT17 in epithelial...