Pharmacodynamics And Mechanism Of Action Study Of Cold Limbs Powder In Treating Experiment Gastric Ulcer

This subject aims at observing if sini powder has the effect of anti-ulcer and elucidating its scientific rationality of anti-ulcer, and initial discuss its effective mechanism through ancient and modern document investigation, empirical study and pharmacology investigation.Traditional Chinese medicine considers that etiological factor and pathogenesis of gastric ulcer are related with disorder of emotional activities, especial involving worry and angry, which leads to stagnation of liver-qi, dysfunction of smoothing and dispersing qi, and wood restraining earth. So based on the differentiation of symptoms and treatment, it should be treated by relieving stagnation and smoothing the liver-qi, as well as regulating the spleen, whose effect is obvious.Duplicate rat peptic ulcer model by means of pyloric ligature, acetic acid daub and irritable methods. Approach sini powder anti-ulcerative mechanism of action based on pharmacodynamics. The conclusion demonstrates with regard to all kinds of chronic and acute peptic ulcer model, sini powder has the conspicuous treatment and precaution effect. Its mechanism of action is related with elevating 6-keto prostaglandin content, SOD level in the gastric mucosa and making acidity total of gastric fluid and pepsin activity, MDA in the gastric mucosa descending, and has not obvious influence on NO. The result demonstrates sini powder may produce a marked effect through both inhibiting damage factor and enhancing defend factor. It can not only authenticate rationality and science of this prescription but also provide experiment theory. So we may know the mechanism of action for regulating the liver and spleen in the traditional medicine. Simultaneously, it has thereference value with regard to directing drugs applicable in the clinic and exploiting new drugs.