| Background and objective:Upper gastrointestinal hemorrhage refers to the hemorrhage of alimentary tract above the ligament of Traitz, including that of the esophagus, stomach, duodenum, upper jejunum, pancreas and biliary tract, of which the hemorrhage of stomach and duodenum takes up 80-90%. Besides the major symptoms of hematemesis and melena, serious patients usually accompany with some clinical features of acute peripheral circulatory failure and insufficiency of some important organs, etc. In recent years, some haemostatic are effective but too expensive. Although hemostusia by endoscope has been widely confirmed, at present the death rate of old people (above 60) who suffer from both the acute and massive bleeding (1/3—1/2) peptic ulcer and upper gastrointestinal hemorrhage has reached high to be 8%-20%, so internal treatment is advocated in curing such diseases. This studying observe curative effect of traditional Chinese prescription ZiHuangYe in treating upper gastrointestinal hemorrhage and to preliminary explore its operation mechanism of curing upper gastrointestinal hemorrhage. Then compared with the west medicine group to find which group is better. Through the check of "OB" and some other checks to provide a safe and effective way for patient of upper gastrointestinal hemorrhage. Method:60 cases were divided into two groups random. The matched controlled group which has 29 cases was treated with Famotidine by IV, (20mg bid), on the base of matched controlled group, the treat group which has 31 cases was treated with ZiHuangYe(50ml po bid). According to some related articles and books, we designed the questionnaire and asked the patients to fill in it before and after treatment .When the investigation is over, we make records about everyquestionnaire and put the data into computer. Finally, we deal with the databy SPSS 11.5 and draw the conclusion.Results:The experiment was adopted randomized double-blind control tests to divide the cases into two groups equally. All of the statistics were analyzed by Package for Encyclopedia Medical Statistics (PEMS). The overall efficiency and effective rates of the treatment group were67. 74% and 87.1%, while those of the control group were 44. 83% and 65. 52% respectively. Both the overall efficiency and effective rates in the treatment group were higher than those in the control group(P<0.05), which indicated that the curative effect of ZiHuangYe powder combined with famotidine on the treatment of digestive ulcer with upper gastrointestinal hemorrhage was superior to that of pure famotidine. Conclusion:Using ZiHuangYe and Famotidine to treat upper gastrointestinal hemorrhage which belongs to the type of heat in the stomach was better than the group treated only by Famotidine in clinical symptom effect curative effect etc. and it can decrease the curative time> less side-effects no obvious character of counteracting drug> cheap price and so on. It develops a new way for the treatment of digestive ulcer with upper gastrointestinal hemorrhage with Chinese medicine. Next step will be taken to expand the number of samples under observation and choose some western medicines of better curative effects (such as Omeprazole) as contrast to further confirm its effects, and observe the curative effects of various endoscope on the treatment of the digestive ulcer with upper gastrointestinal massive hemorrhage compared with gastroscope homeostasis so as to better and more precisely bring the advantages of traditional Chinese medicine into full play.
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