| 0bjective: To study the protective effects of Fosinopril on myocardial ischemia reperfusion injury in rabbits and its mechanism.Methods: Thirty-three New Zealand rabbits (weighting 1.60-2.00Kg were used) were randomly divided into three groups: sham, controland treatment. Each group involves ten rabbits. The rabbits were fed daily with ordinary food. Each rabbit in treated group was additionallyfed daily with Fosinopril (5mg.kg-1.day-1), one week later, the model of ischemia reperfusion was established. Rabbits were anesthetized intravenously with 1% pentobarbital sodium (30mg/kg). Left femoral intubationwas carried out. Opened chest and exposed heart. Rabbis ischemia reperfusion model was carried out by ligation of left anterior coronary descending branch and removing the ligation after 40 min. Sham group:leftanterior coronary descending branch only exposed but not ligated for 100 min. Control and treatment group: ligation of left anterior coronary descending branch for 40 min and reperfusion for 60 min. The changes of S-T segment in electrocardiogram were observed. 10 min before ligation, 40min after ligation and 60min after reperfusion, 2m1 blood was drawn from Left femoral artery to measure the amount of CK-MB and malonaldehyde (MDA), the activity of Superoxide dismutase (T-SOD). The tissue samples removed from I/R areas. The tissue samples were embedded in paraffin after fixed with 10% neutral solution and disposed with routine histological methods. Morphology of myocardial tissue was observed with optics microscopes after staining with hematoxylin and eosin. In the course of experiment, three rabbitsdied. The remaining 30 rabbits were included in the study.
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