Significance Of Brain Natriuretic Peptide In Patients With Acute Coronary Syndrome

Objective: To study the variation and clinical significance of brain natriuretic peptide (BNP) level in patients with Acute Coronary Syndrome (ACS). Methods: The research included 9 healthy persons (control group)and 59 ACS patients. ACS patients were divided into three subsets: unstable angina (UA), ST-elevate myocardial infarction (STMI), non-ST elevate myocardial infarction (NSTMI); and coronary angiography (CAG) was performed in 37 patients. They were also divided into 3 vessels disease group (V3), 2 vessels disease group (V2) and 1 vessel disease group (V1) by CAG. According to Killip class, STMI and NSTMI patients were divided into Killip 4 group (K4), Killip 3 group (K3), Killip 2 group (K2) and Killip 1 group (K1). BNP in plasma was measured by immunoradiometric analysis(IRMA). Results: The plasma BNP level in three subsets of ACS was higher than that control group (P <0.01), and in STMI group was higher than that UA and NSTMI group (P <0.01). According to CAG, The plasma BNP level in V3, V2 and V1 was higher than that control group (P <0.01). The plasma BNP level in K4, K3, K2 and K1 was higher than that in K2, K1(P <0.01). Conclusions: Plasma BNP level increased significantly in ACS. It seems more significant in patients with 3 coronary vessels disease. The severer heart failure was, the higher level of BNP were shown.