The Expression Of HIF-1α And Its Relationship To Apoptosis And Prognostic Significance In Human Glioma

Objective: To explore the expression of HIF-1α in glioma and the relationship between its expression and bcl-2, bax and Prognostic of patients.Methods: Expression of HIF-1α bcl-2 and bax was assessed by immunochemistry staining in 45 cases of glioma and 10 cases of normal brain tissue.Results: HIF-1α was expressed in 28 of 45 (62.2%) cases of glioma, and not expressed the normal brain tissue. There were significant difference between low grade(Ⅰ~Ⅱgrade) and high grade(Ⅲ~Ⅳgrade) of glioma(P<0.05). HIF-1α was significantly correlated with expression level of bcl-2 and bax(r_s=-0.777 r_s=0.720, P<0.01). There also was a correlation between HIF-1α expression and the two-year survival time (P<0.05).Conclusion: The over expression of HIF-1α plays an important role in the apoptosis of glioma. It closely relates with the prognosis of glioma patients.