Analysis Of The Influence Factors On The Prognosis Of Brain Glioma

Objective:Glioma patients were retrospectively analyzed in preoperative, intraoperative and postoperative clinical factors auxiliary treatment for patients with late effects,accurate judgment for clinical prognosis of glioma patients and provide scientific instruction for late treatment.Methods:Collection of shanxi medical university first affiliated hospital of neurosurgery and shanxi province people’s hospital in January 2008- December 2010 hospitalized after surgical treatment of primary glioma patients clinical data were retrospectively analyzed and summarized.With an average age of 42.6 years, age 5-69, 165 cases of male, female 137 cases, male/female ratio of 1.2, according to the scope of the CT,MRI scans to determine tumor by microsurgical resection of tumor and postoperative pathological biopsy confirmed for glioma patients classified treatment.low grade glioma group have most cut groupand all cut set group,treatment of early postoperative radiotherapy and delayed radiotherapy. In high-grade glioma, most cut group and all cut set group have treated pure radiation group,chemotherapy and radiation combine treatment group, two group is comparison result.Patients’ survival time and the result of 1, 3 year survival rate by follow-up to determine the factors(age,pathologic stage, KPS score, etc.) the results of the prognosis for the future.All collecting using SPSS19.0 statistical software for data analysis, using x2 test for survival analysis between different groups, survival rate was calculated by the Kaplan- Meier method and drow the curvep of survival, the single factor analysis with the Log- rank test analysis, by using the Cox proportional hazards model,multi-factor analysis and stepwise regression analysis were risk factors of judgment.Result:1. The single factor analysis: the test analysis of gender and 、tumor range and duration of clinical symptoms had no statistical significancein the different histological grade.these factors are not strong with the prognosis of patients, and in the age, preoperative functional score, preoperative epilepsy have a significant influence on the prognosis and pathology classification.Multi-factor analysis results indicate: the independent risk factors were age, preoperative KPS score, pathologic stage, the three for directly affects the prognosis of patients.2. In low grade gliomasscope of surgical resection that was no significant differencein 1, 3 year survival rate;But early postoperative radiotherapy group 3 year survival rate was lower than those of delayed radiotherapy group and the difference was statistically significant.In the surgical treatment of patients with high grade glioma tumor 1. All cut group1, 3 year survival rate is high to comparamost excisiongroup the difference was statistically significant.2. Put in the treatment of postoperative chemoradiotherapy combined, the treatment group is relatively simple radiotherapy group 1, 3 year survival rate is high, the differences are significant, see the table below.Conclusions:1. High grade glioma patients with multiple with higher age, poor preoperative functional carr’s score is low, low grade gliomas preoperatively common epilepsy.Therefore, factors such as age, preoperative carr’s score, and preoperative epilepsy in the patients with LGG group and HGG group constitutes a significant difference.2. Statistical data analysis in patients with glioma sex, tumor scope, duration of symptoms, and no significant relationship between preoperative epilepsy and prognosis.Independent risk factors affecting the prognosis of patients with glioma is 1age 2 preoperative KPS score 3 pathologic grading.3. For low grade glioma surgery cure should be retained in the process of important neural function under the premise of maximum removal of tumors, should be in the patients with high grade glioma surgery for expanding the scope of the removal of lower residual tumor cells as much as possible.High degree of high grade glioma malignant tissue differentiation at appropriate postoperative line as soon as possible let, chemotherapy treatment;Low grade glioma cells grow slow early may stimulate tumor cells to divide postoperative radiotherapy should be delay line radiation therapy,tumor recurrence or advisable to grow faster.