The Clinical Research Of Soothe The Liver And Benefit The Kidney On Women's Depression

Objective:This text is After using the principle of soothing the stagnation of the circulation of liver's vital energy and benefitting the kidney relieving the uneasiness of body and mind to treat women's depression , study the clinical curative effect and the change of relevant factors that sex hormone level, HAMD grades and the Chinese medicine sign grades.and appling it to big female mouse model which meetting chronic unpredictable emergent to study the change of behaviour , sex hormone , brain cortex form amine neurotransmitter of big mouse . Method:Clinical research: According to the age and illness condition using stratified randomisation divide the 60 depressed women into treated group and contrasted group . The treated group adopted with the method of soothing the liver and benefitting the kidney for 12 weeks, the contrasted group treated with Paroxetine. Record the grades of HAMD and the Chinese medicine sign before and after treatment then compare them. And determine serum E₂ , P , PRL of the depressed patient and health person.Experiment study: 72 big female mice in according with the standard range of open-field result divided into normal group,model group,Western medicine group,traditional Chinese medicine group at random. Using Open-field behaviour determine and the syrup consuming experiment , observes the curative effect contrast, and determine E₂ , P , PRL and 5-HT , DA content. Result:Clinical research: eproduction endocrine hormone level and HAMD grade and HAMD 4 factors have dependence relationship. After soothing the liver and benefitting the kidney, E₂ rises notably and PRL drops notably. The treatment result is remarkable and equal with Paroxetine ,but has lightenned Paroxetine's the side effect of poor appetite and sick or vomits. Experiment study: With the methord that Soothe the liver benefit the kidney and take Paroxetine ,the curative effection is remarkable. The model group of E₂ drops notably,5-HT and DA is lower than nomal, E₂ of traditional Chinese medicine group goes up notably after treated, and P , PRL drop notably, 5-HT, DA rise notably. the group treated in the traditional Chinese medicine is superior to in Western medicine. Conclusion:Reproduction endocrine hormone correlate to the severe condition of the depression. The method of soothing the liver and benefitting the kidney can regulate women's sex hormone level of depression patients, and the result of treatment is remarkable and safe.