Odontogenic Tumors: Clinical And Pathological Analysis Of 1138 Cases

Odontogenic tumor is made up of a series of tumors or tumor-like lesions arising from dental formative tissue. Despite the obvious need to know the incidence and relative frequency of odontogenic tumors, there are surprisingly few such studies especially with studies in Chinese. Meanwhile, there is considerable coutroversy regarding the relationship of histologic subtypes to clinical features of ameloblastoma, which is the type most commonly seen among odontogenic tumors.This paper reviews and summaries the pathological and clinical material of 1138 cases of odontogenic tumors submitted to the Oral Pathology Biopsy Service, Sichuan University. Each slide of cases stained by hematoxylin-eosin was revaluated by pathologists of the Department of Oral Pathology of our colloge on the base of curerent WHO(1992) classification. Clinical Material was obtained from case record of inpatients. All pathological and clinical material was statistically analysed by SPSS in microcomputer. In this study, theresults of retrospective study of 1138 cases representing the status of odontogenic t umors i n Chinese a re p resented. The d ata c ollected o n age, gender, location and clinical presentation were analysed and discussed. Meanwhile, much special reference was given to the correlations of histopathologic subtypes to clinical features of ameloblastoma. The results indicated:1. Ameloblastoma was the type of odontogenic tumors most commonly seen in 1138 cases. This conclusion is quite different to that from reports of North America, where odontoma was much more often than ameloblastoma was.2. Of the 1138 patients in this study, a mild male preponderance was found with a male to female ratio of 1.3:1. This feature of g ender distribution w as a lmost s een i n e very d ecade o f the life.3. Odontogenic tumors were seen more often in the 1st to 4th decade of life, except the maliganant ameloblastoma and the primary intraosseous carcinoma, both of which were usually found in periods of life older than 4th decade.4. Most odontogenic tumors(75%) were found in the mandible, especially in the region of molar tooth. With the exception of odontomas in the anterior parts of upper jaw, ameloblastoma was the tumor most commonly seen in both upper and lower jaws.5. Ameloblastoma i n Chinese s howed a greater t endency t o occur in the mandible while the upper to lower ratio is 1:11.8. Thisratio is much higher than that of reports from Europe and North American.6. Incidence of recurrence in ameloblastoma managed by currettage or enucleation was much higher than that of ameloblastoma by partial or complete osteotomy of jaws.7. Desmoplastic ameloblastoma(DA) in this study only showed a tendency to occur in anterior part of lower jaw instead of both upper and lower jaws as indicated by other reports. Incidence of recurrence in DA showed no statistically significant difference to that of other variants of ameloblastoma.