| Objective : To investigate the relationship among psychosocial factors, some biological factors and essential hypertension, to observe the change of blood pressure after being given antidepressants. Methods : A series of scales(MMPI , LES , SS , HAMA , HAMD) , Corticosteroid , Adrenocorticotropic Hormone and Platelet 5-HT were studied in 98 patients with essential hypertension and 60 controls. Among them ,fifty patients were divided into A group and B group. A group were given Benazepril. B group were given Benazepril and Paroxetine. The blood pressure change and score change of HAMA, HAMD were compared between A group and B group after 28 days. Results : The scores of the EH patients in the scales of F, Hs, Sc, D, Pd, Pt and Si in MMPI was different from that of controls. Patients with EH had higher scores in the scales of LES, HAMA and HAMD and lower scores in SS scale compared with the control group(p<0.05). There was positive relation between the change of HAMA, HAMD scores and the change of blood pressure,especially in HAMA. The value of corticosteroid in patients was higher than that in controls, and ACTH was lower. The value of corticosteroid had some relationship with anxiety. The blood pressure change of B group was much more than that of A group(p<0.05). Conclusion : EH patients have certain personalities, higher psychosocial stress and lower social supports. Negativeemotions such as anxiety and depression are prevalent in EH patients. Anxiety and depression have relations with blood pressure, especially anxiety. HPA axis activation exists in EH patients. Anti-anxiety and anti-depression therapy can help to reduce blood pressure and change activity of HPA in EH.
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