Study On Immunity Function Of Patients Of Chronic Hepatitis B With Syndrome Dampness-heat Retention Spleen

Objectives:TO observe the change of the T-lymphoid cell, The NK cell,immunity globulin and complement etc. in sufferer's of chronic hepatitis B (CHB abbreviate) with syndrome Dampness-heat retention spleen(DH), understand each immunology index sign to the influence of this type's pathology mechanism. understand further the relation of immunology function and CHB. Meanwhile, the Liver qi depression spleen deficiency type (LS), explore the feature of different type immunity expresses, give the Chinese medicine certificate with the content of immunity science, expect to serve betterly for the clinical cure.MeThod: Ninety patients of CHB were divided into two groups by syndromedifference of TCM, DH group (60 cases) and LS group (30 cases). DH group included 30 cases treated by routine treatment(RT) and 30 cases treated by integrated TCM(IT), consisted of 30 cases each group, with one month coures of treatmen -t. Through measuring the pacients' ALT, AST, TBIL,vinus replication index,T -lymphoid cell, The NK cell, immunity globulin and complement etc in DH, LS, DH' two treatments before and after, inquire and compare each immunity index sign and the relation of DH and LS; observation DH two treatments in front and back each index sign and certificate integral calculuses change, comparing The treatment in front and back machine immunity function appearance.Results:(1) The levels of ALT, AST, TBIL were higher significantly (P<0.01) in the patients of DH than normal value; The levels of of LS ALT, AST were higher in the patients of LS than normal value, the difference shows obviously (P<0.01), TBIL compares with normal value did not show obvious difference (P>0. 05); ALT, AST, TBIL showed obvious difference in two groups (P<0.01). (2) The levels of CD3, CD4, IFN-γ were lower in the patients of DH than normal value(P<0.01), CD8, IgG, IL-10 were higher than normal value,the difference showed obviously (P<0. 01), NK, IgM, IgA, C3, C4 compares with normal value to did not show the difference obviously (P>0. 05); The levels of CD3.CD4, C3, IFN- y were lower in the patients of LS than normal value (P<0. 05, P<0. 05, P<0. 01, P<0. 05), IL-10 was higher significantly than normal value(P<0. 05), CD8, NK, IgG, IgM,IgA, C3, C4 compares with normal value did not show obvious difference(P>0. 05); CD3, CD4 CD8, IgG, C3, IFN-y showed obvious difference in two groups(P<0. 01), IL-10 showed difference (P<0. 05). (3) The levels of ALT, TBIL in the patients of DH and LS descend, curing in front and back the difference showed obvious(P<0.01); AST descends, curing in front and back shows obvious difference(P<0.01, P<0.05); two treatments did not show the obvious difference behind (P>0.05). (4) The levels of CD3, CD4, IFN-y in the patients of IT gone up, curing in front and back showed the difference obviously (P<0.01), CD8, IgG descended, curing in front and back showed obvious difference (P<0. 05, P<0. 01), NK, IgM, IgA, C3, C4, IL-10 of the treatment did not show obvious difference in front and back(P>0.05); the patients of LS empress CD3, CD4, IFN-r gone up, curing in front and back showed obvious difference(P<0. 05, P<0. 05, P<0. 01), The levels of CD8, NK, IgG, IgM, IgA, C3, C4, IL-10 in the patience of RT hadn' t obvious difference in front and back(P>0. 05); two treatments compare behind CD3, CD4, CD8, IgG the difference of IFN-y was obvious(P<0. 01); NK, IgM, IgA, C3, C4, IL-lOwerenot obvious difference (P>0. 05). (5) In the aspect of transforming IIBeAb negative into pasitive there is one case of each group, others had no obvious change. (6) In improving curative effect and in decreasing the marks of syndrome IT were super to that of TR. Conclusions: (1) The levels of CD3, CD4, IFN-y in the patients of CHBwith DH are obvious to descend, CD8, IgG, IL-10 are rising than normal value, NK, IgA, IgM, C3, C4 have no obvious difference with normal value, the difference of the immunity index sign is obvious in DH and LS, the patients of DH immunity answer can be stronger than LS, explaining the sufferers in CHB exsit immunity function mess phenomenon. (2) There is big difference in IgG,C3 of CHB DH and LS, IgG, C3 may be a research to distinguish analyse two cert i f icate types consul ts index sign, C3 may be recognize truth or falsity consults index sign, this treatin further to take into the proof. (3) DH and LS are patient' s condition unsteady course in CHB, DH' s pathology is more seriors than that of LS; prognosis of CHB can be relation to immunity function, Chinese medicine dialectics treatment can regulate the immunity function of the sufferer in CHB with DH availably, we should attach importance to it.