Study On Blood Stasis Of Patients Of Chronic Hepatitis B With Syndrome Dampness-heat Retention Spleen

Objectives: By means of treatments of Yin-shao-san of antipyretic dryingdamp and blood stasis remove and of Yin-shao-san of single antipyretic drying damp without blood stasis remove respectively, to demonstrate the situation of blood stasis in patients of Chronic Hepatitis B with syndrome dampness-heat retention spleen and to provide proof for clinic cure.Method: 64 patients of Chronic Hepatitis B with syndrome damp-heatretained in spleen were divided randomly into two groups: control (CT) group and comparison (CP) group, 32 cases in each group. CT group was treated by Yin-shao-san, antipyretic drying damp and blood stasis remove, and CP group was treated by Yin-shao-san, only antipyretic drying damp without blood stasis remove, both in one month course. The patients' serum levels of ALT, AST, TBIL, virus replication indes, HA, IV-C, TXB2, 6-K-PGF1a were measured and the marks of syndrome were recorded before and after treatment. Data were dealt with and analyzed by statistic software SPSS.Results: (1) The levels of ALT, AST, TBIL were higher significantly (P<0. 01)in serum of the patients than the criterions. The levels in serum of CT and CP groups after treatment were both obviously lower than those before treatment (P<0. 01). But there was no significantly difference between the two groups in decreasing the levels (P>0.05). (2) The levels of HA, IV-C were higher significantly (P<0. 01) in serum of the patients than the criterions. The levels in serum of CT and CP groups after treatment were both obviously lower than those before treatment (P<0. 01), and the effects of CT group in decreasing the levels of HA, IV-C were superior to CP group (P<0. 05). (3) The level of TXB2 was higher significantly (P<0. 01, P<0. 05) in serum of the patients than the criterions and the level of 6-K-PGF1a in serum of the patients was no difference in comparison with the criterions (P>0.05). The levels of TXB2, 6-K-PGF1a and the ratio TXB2/6-K-PGF1a in serum of CT and CP groups after treatment were both obviously lower than those before treatment (P<0.01). But there was no significantlydifference between the two groups in decreasing the levels (P>0.05). (4) There was no significantly difference before and after treatment in virus replication indes and liver Doppler B, both two groups. (5) The curative effect of CT group in decreasing the marks of syndrome was superior to CP group (P<0.05).Conclusions: (1) Blood stasis exists in patients of Chronic Hepatitis Bwith syndrome damp-heat retained in spleen and blood stasis remove should be paid attention to in treatment. (2) The changes of the serum levels of HA, IV -C and TXB2, 6-K-PGF1a objectively indicate partially the essence of blood stasis of Chronic Hepatitis B so that HA, IV-C and TXB2, 6-K-PGF1a could be regarded as objective indes of blood stasis.