| Cerebrovascular diseases are encephalopathy because of all kinds of brain' s change of diseaseso Cerebrovascular diseases angiocardiopathy and tumor have become three major causes of death in human's diseases How to prevent Cerebrovascular diseases is the focous to all over the world Chinese herb of activating blood flow and removing blood stasis is used broadly in the treatment of ischemic Cerebrovascular diseases with symptom of blood stasis in clinic Herbal medicine huonaokang is an important Traditional Chinese medicine with activating blood flow and removing blood stasis is an important composed component of all kinds associate decoctions In order to demonstrate the mechanism of herbal medicine therapy in acute cerebral ischemia rats of model, we have studied it systemlyIn this subject, the healthy rats of Wistar strain were selected as experimental study objects 80 rats were divided into five groups by random To imitate the pathologic chang caused by acute cerebral ischemia damage in human, the animal model were made by blocking middle cerebral artery,. We adopted immunohistochemialc method, regarding manipulating apoptosis gene aspect, apoptosis DNA fragmentation degree, immunity change and growth-associated protein ect as study indexes We constrasted the difference among different groups at 10 days after the operation by herb medicine therapy and tried to show the fanction and mechanism of itoThe result show, ( 1) herb medicine therapy can decrease the expression of accelerated apoptosis gene P53 protein around cerebral infarction and reduce nerve cells apoptosis significantly; ( 2 ) Decline cells apoptosis programme caused by DNA broken and reduce cerebral ischemia damage and increase protected function of brain; ( 3) Restrain the expression of inflammatory reaction cytokine...
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