Correlation Between Expression Of P33/ING1 And P53 Protein And Apoptosis In Colorectal Carcinoma

Objective: To explore expression of p33/ING1 and p53 protein and their effect in the genesis and progression of colorectal carcinoma. Methods: Expression of p33/ING1 and p53 in sixty colorectal cancerous tissues and the normal mucous tissues was examined by immunohistochemistry methods. Apoptosis of sixty samples was detected by TUNEL technique. Results:1. Twenty-six of 60 (43.3%) cases expressed p33/ING1 protein in colorectal cancerous tissues, while the normal mucous tissues of all samples expressed p33/ING1 (100%). There was a significant difference between the two groups (P <0.01). The positive rate of p33/ING1 expression in cancerous tissues of Dukes A and B was significantly higher than those of Dukes C and D. (56.7% VS 30.0%), but no correlation with other clinopathologic features.2. p53 was expressed in 31 of 60 (51.6%) cases of colorectal cancerous tissues, all samples of normal mucous tissues did not express p53 (0%). There was a significant difference between the two groups (P <0.01). The positive rate of p33/ING1 expression was significantly lower in p53-positive group than that in p53-negative group (29.0% VS 58.6%). There was a significant difference between the two groups (P <0.05). A correlation coefficient test shows a...