Expression Of P73,p53,p21～(WAF) And Relationship With Apoptosis In Colorectal Carcinoma

Objective:To investigate the expression of p73, p53, p21^WAF in colorectal carcinoma, the possible correlation in three proteins and apoptosis, and their role in Colorectal carcinoma .Methods:Expression of p73, p53 , p21^WAF protein in Colorectal carcinoma was examined by immunohistochemistry methods(S-P). Similarly, apoptosis in colorectal carcinoma was exmamined by TUNEL technique. The result of the examinamtion was statistically analyzed.Results:1. Expression of p73 in Colorectal carcinoma was 58.3%(28/48), heigher than in Colorectal tubular&villous adenoma, Edge of colorectal tissue. There were very significant differences in histodifferentiation , Dukes stage of Colorectal carcinoma,lymphatic metastasis.2.The expression grade of p73 was positively correlated with the expression grade of p53 protein,and it was unrelated with the expression grade of p21^WAF protein . The expression grade of p53 was negatively correlated with the expression grade of p21^WAF protein .3. Expression of p53 in Colorectal carcinoma was 47.9%, that of p21^WAF was 93.8%.4. The apoptosis indexes(AI) in Colorectal carcinoma was 10.27±1.23‰,...