The Study Of Relationship Between Serum Ferritin And Type 2 Diabetes

Recently, more and more experimental and clinical studies on iron metabolism have confirmed pathologic iron accumulation affects many organs, such as the liver, pancreas and heart and iron overload can facilitate the occurrence of a variety of disease, including cirrhosis, congestive heart failure, diabetes, and cancer. Type 2 diabetes is a common manifestation of hemochromatosis, a disease of massive iron overload, which has to speculation that high iron store may increase the risk of developing type 2 diabetes. Emerging scientific evidence has disclosed influences between iron metabolism and type 2 diabetes. The relationship is bi-directional -iron affects glucose metabolism, and glucose metabolism impinges on iron metabolic pathways. Oxidative stress and inflammatory cytokines influence these relationships, amplifying and potentiating diabetes.Serum ferritin is a widely used marker of iron status and accurately reflects difference in body iron stores by age and sex. Serum ferritin concentration is the most closely mirror the total body iron content. So we can apply the relationship between serum ferritin and type 2 diabetes to illuminate the relationship between body ironburden and type 2 diabetes. In overseas clinical studies, elevated ferritin levels have associated with coronary heart disease, diabetes, hypertension, and tumor. But domestic studies of relationship between serum ferritin and type 2 diabetes are few. In order to investigate the relationship between serum ferritin and type 2 diabetes and components of the insulin resistance syndrome, we evaluated abdominal obesity, systolic and diastolic blood pressure, blood glucose, serum HDL cholesterol, serum triglycerides, C-reactive protein, and serum ferritin in type 2 diabetes and healthy controls. We want to study the relativity between serum ferritin and insulin resistance and type 2 diabetes.A total of 76 patients with 2 type diabetes were entered into study. We excluded the patients with suspected inflammation, infection, liver disease and so on. 69 healthy volunteers with no diabetes, coronary heart disease, hypertension, cerebrovascular disease family history were recruited. All subjects were evaluated BMI (calculated as weight in kilograms divided by height in meters squared) and the waist-to-hip ratio (WHR). Blood pressure was measured after rest. After the subjects had fasted 8-12 hours at the time examination, fasting and post-prandial glucose levels, serum HDL cholesterol, serum triglycerides, serum ferritin and C-reactiveprotein were examinated. Insulin resistance was determined using the homeostasis model assessment (HOMA) estimate of insulin resistance HOMA -IR= [fasting insulin (uU/ml)Xfasting glucose (mmol/L) ] /22.5.Parameters that did not fulfill normal distribution were log transformed. We used t test for comparisons of parameters between two groups and multiple regression analysis was performed. Levels of statistical significance were set at P<0.05. The results in the studies are showed as follows:1. Individuals with diabetes had higher systolic blood pressure, triglyceride concentrations, BMI, WHR, serum C-reactive protein concentrations, and fasting insulin concentrations and had lower HDL cholesterol concentrations than individuals with normal glucose concentrations.2. Newly diagnosed diabetes had statistically higher ferritin concentrations among men and women.3. Log-transformed serum ferritin correlated positively with TC, TG, LDL-C, CRP, FBG, PBG and HOMA-IR, negatively with HDL-C, but not with BMI, WHR, SBP and FINS. Using multiple regression analysis, we found that though BMI is the main effective factor of HOMA-IR, SF also is independent variable.Elevated serum ferritin levels independently predicted incident type 2 diabetes in prospective studies. Serum ferritin levels correlated with insulin sensitivity in several different populations, including individuals without diabetes, individuals with diabetes, women with gestational diabetes, and patients with thalassemia. In cross-sectional studies, elevated ferritin levels have been associated with hypertension, dyslipidemia, elevated fasting insulin and blood glucose, and central adiposity. The population with impaired glucose tolerance and normal tolerant first-degree relatives in type 2 diabetic pedigrees had higher ferritin concentrations than normal controls. There is well relativity between blood glucose and serum ferritin and after the treatment with iron chelators such as deferoxamine, blood glucose would improve paralleling reductions in serum ferritin.We used the homeostasis model assessment (HOMA) estimate of insulin resistance and synthetically evaluated association between serum ferritin and components of insulin resistance syndrome. In our study: serum ferritin were negatively correlated with insulin sensitivity. Furthermore, serum ferrintin was positively correlated with systolic blood pressure. In this sense, when the body iron stores have been depleted, the blood pressure would reduce. Serum ferritin also was inversely correlated with HDL. This outcome illuminated...