| Idiopathic inflammatory myositis is a group connected tissuediseases of pathological changes which cross striated musclechronic nonsuppurate inflammation , some of those with mark skinalterant .Etiology and pathogenesis of idiopathic polymyositis/dermatomyositis is still quite clarity . Infection factors , hereditybackground , environment complications and malignancy areinducements of this guoup diseases by any possibility . At thepresent it is considered that it is a immunity-mediated processcaused by environmental factors which cause to musculaturedamage in some heredity susceptibility individuals.This article analyses clinical data of 59 cases of inflammatorymyopathy( 43 of dermatomyositis and 16 of polymyositis)retrospectively, and analyses those of clinical manifestation ,laboratory examination, treatment and turnover conditions to aim atprobe clinical onset fearures of inflammatory myopathy . this isvery significant to be diagnosised early and estimate therapeuticeffect and prognosis.The results showed that patients at the age of 30-44 accountsfor 50.8%, and male-female rate is 1:3.21. The incidence rate ofonset symptom are rash , rash and muscle symptom , musclesymptom one by one in 43 cases of dermatomyositis. Rash ismultiformity , Dermatomyositis also have characteristic cutaneousmanifestations , turgescence amaranth splash on the socket eyewith the central of both upper eyelids and Gottron sign onmetacarpophalangeal and proximal interphalangeal jointsextendside .these rash is of important diagnostis value .Clinical manifestations of this disease is symmetrical proximalmuscle atony , pelvis and capular muscles to be involved mostfrequently , include muscle atony , myalgia , sweeny ; Laboratoryexamine such serum muscle enzyme level increase , especiallycreatin kinase . Serum creatase raise up in 55 untreatedcases( about 94.8%), LDH and AST more sensitive, secondlyHBDH and CK ,finaly ALT and CK-MB. In which Both AST andALT raise up the degree of AST ,the degree of AST descend is priorto that of ALT.The sensitivity of AST is higher than that ofALT .When both of them raise up , AST is often higher thanALT ,this is favor to distinguish inflammatory myopathies fromliver cells damage . 68.3% patients have the abnormalcardiograph .There is no statistic discrepancy on CK-MB inpatients with heart damage or not .Electromyography show inflammatory myopathies change,positive rate 85.4%.Tissue pathology show inflammatorytransformation , mostly are inflammation cell soakage and musclefibre denaturalization/ putrescence/ atrophy/ palingenesis . Most ofsoakage cells are lymphocytes , next macrophagocytes , andpolymorphonuclear leukocytes little . Positive rate of tissuepathology is 88.2% , prior to positive rate of Electromyography. Soif condition allow , we should do muscle pathology . All of 3cases(5.08%) with malignancy are female dermatomyositispatients ,older than 40 years, before or the same time or after . Oneolder than 40 with tetter should do a whole examination to findout malignancy who have this disease lease than 4 years . the maintherapy of those is glucocorticoids associated with cytotoxicagents . 25 cases are treated with only glucocorticoids or combineto immunosuppressive agent ,after 2 weeks there are disparitydegree recovery and creatase change . CK,CK-MB,LDH showdifferent degree of decrease ; there is no statistic discrepancy onAST and HBDH , while ALT increase, we consider that may beassociated with the increase of transaminase partly becauseimmunosuppressive agents lead to liver cell damage .According to this study outstanding , we can draw thefollowing conclusion :Firstly , females at the age of 30-44 appear tetter with myalgia\ muscle atony , inflammatory myositis ( polymyositis /dermatomyositis ) should be considered first of all .Secondly , on the inflammatory myositis ( polymyositis /dermatomyositis ) in muscle enzyme the changes of LDH and ASTare more sensitive , while those of ALT and CK-MB are the lowest .Wherever CK increase distinctly best of all . The increase of...
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