Association And The Levels Of Leptin,Interleukin-6 (IL-6) In Serum Of Acute Cerebral Infarction Patient

Objective:to explore the levels of Leptin,interleukin-6(IL-6) in serum of acute cerebral infarction patient and the association of Leptin level with IL-6,blood pressure, blood fat and fibrinogen,and to investigate the role of the serum Leptin,IL-6 in patients with cerebral infarction(CI). Methods:the serum concentration of leptin and IL-6 in 60 patiens with CI,40 healthy controls were measured by means of radioimmunoassay,and to measure the blood pressure and the serum concentration of the blood fat, fibrinogen and to analysis the association of these indexes. Result:compared with those in the controls,there were elevation of serum leptin leve(lP<0.05) and IL-6 leve(lP<0.01).The serum leptin level related positively to the level of the IL-6(r=0.512,P<0.01)and the LDL(r=0.453,P<0.01),the total cholesterol(r=0.326,P<0.01),the triglyeride(r=0.435,P<0.01),the blood pressure(r=0.313,P<0.05), related negatively to the HDL level(r=–0.262,P<0.05).There is no relation between the leptin and the fibrinogen.in the patients with CI. Conclusion:the elevation of serum leptinlevel and the overexpressionof IL-6 is the appearance of neuroendocrine functional disorder in the patients with acute cerebral infarction.The level of leptin had close relation to IL-6 and related closely to the risk factors of cerebrovascular disease.Leptin and IL-6 participated the development of cerebral infarction together.