| Bladder transitional cell carcinoma (BTCC) is the most common malignant tumor in urinary system. Postoperative recidivation and metastasis are common reasons lead to failure of treatment. The occurrence and growth of tumor correlate with the activation of oncogene and the mutation and/or absence of anti-oncogene. Anti-oncogene PTEN, also called PTEN/MMAC-1/TEP-1, is the first anti-oncogene which has activity of phosphatase, after 1997 which year it was found, PTEN was paid extensive attention to in cancer research area. New vessels is the base of the growth and metastasis of tumor. VEGF protein is considered the most effective and specified regulator of angiogenesis. It correlate with many tumors including BTCC. AIM To approach to the effect of PTEN and VEGF in the process of the occurrence and growth of bladder tumor and their clinical value. METHODS Expression of PTEN and VEGF were detected in 60 specimens of bladder tumour and 10 of normal tissue by using immunohistochemistry test (SP method). RESULTS The positive rate of PTEN was 100% (10/10) in the tissue aside from the tumor while it was 47% (28/60) in bladder transitional cell carcinoma. The positive rate of VEGF was 0 (0/10) in the tissue aside from the tumor while it was 68% (41/60) in BTCC. Expression of PTEN in well and moderately differentiated BTCC was respectively 72.7% (16/22 ) and 40%(10/25), and in poorly differentiated tumor, it was 15.4%(2/13). In different clinical stage, the positive rate of PTEN was... |
