Multiple Primary Malignant Neoplasms In Urogenital System (Report Of 19 Cases)

Objective:To improve the diagnosis and treatment of multiple primary malignant neoplasms in urogenital system(MPN) by investigating the clinical features of MPN. Methods:19 urogenital malignant tumor patients with multiple primary malignant neoplasms (MPN) in the period of 1998 to 2005 were studied retrospectively. The MPN in urogenital system was investigated, and the diagnosis, classification, incidence, etiology, treatment and prognosis ofMPN were discussed in the light of literature. Results:The percentage of multiple primary malignant neoplasms was 3.9% in all the genitourinary malignant neoplasms investigated. 12 (63%) multiple primary malignant neoplasms located in bladder. 9 (47.4%) patients have family case history of the malignant neoplasms. Ratio of male to female was 15:4. In the 11 patients with synchronous occurrence of multiple primary malignant neoplasms, 1 patient was lost, 4 patients died after 2 months ~ 17 months, with a mean of 7.25 months, the others have survived 14 months to 60 months after the operation. In the 8 patients with asynchronous , 3 died after 1 months to 10 months, 5 have survived 7 months to 24 months after the second carcinoma being treated. There in no significant difference in the mean age or survival rate between the synchronous and the metachronous. Conclusions:1. The susceptible organs of multiple primary malignant neoplasms are urogenital system.2. Multiple primary malignant neoplasms of urogenital system is more frequently seen nowdays and a successive malignant growth should be awared of and the prompt detection and treatment of the secondgrowth is of prime importance.3. It was emphasized that multiple primary malignant neoplasms was different from late metastatic cancer, so the significance of the differential diagnosis between multiple primary malignance and metastatic cancer is important for patients with multiple malignancies.4. Multiple primary malignant neoplasms must be detected as early as possible. Early diagnosis and adequate treatment of each malignant neoplasms is the only means to achieve along survival.5. The main treatment should be operation combined with chemoradiotherapy, immunopotentiator and traditional Chinese medicine for multiple primary malignant neoplasms in urogenital system.6. The patient should be closely followed up after the first carcinoma being treated.7. The high risk population with tumor history-hentage should be warned of possibility of multiple primary malignant neoplasms in urogenital system.