| ObjectiveTo investigate the clinical pathology characteristics, the location, time interval and prognosis of the multiple primary malignant neoplasms?MPMNs? with breast cancer patients. Methods We retrospectively analyzed 90 breast cancer patients with MPMNsbetween January 1996 to December 2014 in Tianjin Medical University of Cancer hospital. The data was input by Access 2007 and statistical analysized by SPSS 16.0. By immunohistochemistry, we detect the expression of ER, PR, HER-2, Ki67, P53 in breast tumor parafin section. ResultsThe median overall survival of all patients was 99 months. 42 patients were first diagnosed with breast cancer,3-year overall survival rate was 97.8% and 5-year overall survival rate was 83.3% respectively.50 patients were first diagnosed with othercancers,the3-year overall survival rate was 98.1% and 5-year overall survival rate was 82%,respectively.The interval between breast cancer and other cancers was 0258 months. The median interval was 49 months.Univariate analysis showed that the age of the first cancerdiagnosed(P = 5.0×10-3),the staging?P = 0.019?, P53(P = 3.5×10-4) and Ki-67?P = 0.012? associated with breast cancer is the main prognostic factor of disease-free?the time interval between two cancers? survival of first cancer.Theageof the first cancer diagnosed?P = 0.019?,the staging?P = 0.015?,the time interval between two cancers?P = 0.011?and the categories of first cancer(P = 2.7×10-9), P53(P = 1.6×10-4) and Ki-67(P = 9.0×10-3) associated with breast cancer is the main prognostic factor ofoverallsurvival of first cancer. The staging of the second cancer(P = 5.1 × 10-3), P53?P = 0.015?associated with breast cancer and the tumor size of the breast(P = 3.1×10-4)is the main prognostic factor of disease-freesurvival of the second cancer. The staging?P = 0.010?,the time interval between two cancers?P = 0.011?and the categories of second cancer?P = 0.010?, P53(P = 8.7×10-3)associated with breast cancer and the tumor size of the breast(P = 3.1 × 10-4) is the main prognostic factor ofoverallsurvival of the second cancer.Multivariate analysis showed that, the age of first cancer diagnosed?P = 0.015?,the staging?P = 0.046? and the time interval between two cancers?P = 0.009?were independentprognostic factors of first cancer's overall survival. If breast cancer comes the first, theage of first cancer diagnosed?P = 0.019?,the staging?P = 0.025? and P53?P = 0.018? were more important. If breast cancer comes the second,theage of first cancer diagnosed?P = 0.037?,the staging?P = 0.021? become more important. The age of second cancer diagnosed?P = 0.018?,the staging?P = 0.023?were independentprognostic factors of the second cancer's overall survival. If breast cancer comes the first, the staging?P = 0.026? was more important. If breast cancer comes the second,theprognostic factors were not clear yet. ConclusionsThe age of first cancer diagnosed,the staging, P53 and Ki-67 associated with breast cancer were independentprognostic factors of disease-free?the interval time between two cancers? survival.Theageof the first cancer diagnosed,the staging,the time interval between two cancersand the categories of first cancer, P53 and Ki-67 associated with breast cancer is the main prognostic factor ofoverallsurvival of first cancer. The staging of the second cancer, P53 associated with breast cancer and the tumor size of the breast is the main prognostic factor of disease-freesurvival of the second cancer. The staging,the categories of second cancer, P53 associated with breast cancer and the tumor size of the breast is the main prognostic factor ofoverallsurvival of the second cancer. According to the first cancer's overallsurvival, if breast cancer comes the first,theage of first cancer diagnosed,the stagingand P53 were more important, if breast cancer comes the second,theage of first cancer diagnosed,the stagingbecome more important. According to the second cancer's overallsurvival, if breast cancer comes the first, the staging was more important, if breast cancer comes the second,theprognostic factors were not clear yet. |
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