Analysis Of Clinical Features And Survival For200Patients With Multiple Primary Malignant Tumor

Objective:To explore clinical features, treatment and prognosis of multiple primary malignant tumor, and survival analysis for200cases of patients with multiple primary malignant tumor.Methods:Retrospective analysis was performed on patients with multiple primary malignant tumor in all malignant tumor patients permitted in the oncology department of the First Affiliated Hospital of Soochow University from November2006to December2012, explore clinical features of multiple primary malignant tumor, compare1to5-year’s survival rate of radical treatment to non-radical treatment and metachronous to synchronous tumors.Results:There were7690cases of patients with various types of malignant tumors in our department during the past six years, including200cases of multiple primary malignant tumor, accounting for2.60%. The male to female ratio was101to99(1.02:1). The age of onset was between29and84years old, averaged54.2years old, and the prevalence peak age is51--60years old. In200cases of multiple tumors,186cases were double cancer (93%),12cases were triple cancer (6%),1case was quadruple cancer (0.5%), and1case was six heavy carcinoma (0.5%). In the200cases,56cases were synchronous (28%) and144cases were metachronous cancers (72%), with the interval of onset from7to372months, averaged62.1months, median time interval was38.5months. The frequency of respiratory system in the second tumor is higher than that in the first tumor (P<0.05). The frequency of head and neck in the second tumor is lower than that in the first tumor (P<0.05).Regardless of the first or the second tumor, digestive system frequency are significantly higher than in other organs. There is no significant difference in cancer and sarcoma constitute of200patients in the first tumor and the second tumor. All patients followed up to December2012, the survival period was1～360months, with an average of29.5months, median survival time was19.6months.1to5year’s overall survival rates were respectively69%,39%,24%,14%,10%. Cumulative survival rate of the group completely radical treatment was significantly higher than that of the insufficiency radical treatment group and the non-radical group (P<0.01). There is no significant difference in cumulative survival rate between the insufficiency radical treatment group and the non-radical group(P>0.05).Also, there is no significant difference in the survival rate of metachronous and synchronous multiple primary tumors.Conclusion:1. Multiple primary tumors usually occur in the elderly. There is no significant difference in sex and in age of men and women.2. Double primary tumor is more common than others, metachronous multiple primary tumors are more than synchronous multiple primary tumors.3. The frequency of respiratory system in the second tumor is higher than that in the first tumor. The frequency of head and neck in the second tumor is lower than that in the first tumor. Frequency of digestive system is significantly higher than in other organs.4. There is no significant difference in cancer and sarcoma constitute of200patients in the first tumor and the second tumor.5. There is no significant difference in tumor stage at the time of diagnosis of the first tumor and the second tumor.6. Cumulative survival rate of the group completely radical treatment was significantly higher than that of the insufficiency radical treatment group and the non-radical group. There is no significant difference in cumulative survival rate between the insufficiency radical treatment group and the non-radical group, neither between metachronous and synchronous multiple primary tumors.