| Objective To Measure the levels of plasma endothelin(ET) and calcitonin gene related peptide(CGRP) in patients with migraine and explore the significance of the changes in the development of migraine, and to offere evidence of preventing the migraine occurrence. Methods 34 patients with migraine which attained the diagnostic principle and divided into attack period and headache-free period were choosed and taken vein blood to analyze the levels of plasma ET and CGRP by radioimmunoassay(RIA) method , and the concentration of plasma ET and CGRP were compared with control group composed of 31 healthy persons. 22 patients during migraine attacks were observed the therapeutic effect and measured the changes in plasma content of ET and CGRP before treatment and after treatment with sibelium. Results The levels of ET and CGRP in migraine were obviously higher than those in controls(p<0.01) ; the levels of ET during serious attacks was higher than that during slight attacks and headache-free period (p<0.05,p<0.01);the content of CGRP during slight attacks and headache-free period was higher than that in controls(p<0.01,p<0.05),and the concentration of ET during slight attacks was higher than that in controls (p<0.05). There was positive relativity between the levels of ET and CGRP in controls (r=0.5860,p<0.01)and headache-free period (r=0.6047,p<0.05).The level of plasma CGRP of migraine attacks was remarkedly reduced after treatment with sebelium(p<0.01). Conclusion The level changes of plasma ET and CGRP in patients with migraine might be related to the outbreak of acute migraine.
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