Clinical Research Of Treating Hypokinesia Type And Rigid Type Parkinson's Disease With PD NO.1

Objectives:Parkinson's disease (PD) is a degenerative disease of nervous system, which is common in middle or/and old peoples. Incidence of PD is raising as the age increases. Researches on the hypokinesia type and rigid type are scarce since PD was divided into for clinical types. Hypokinesia type and rigid type account for twenty percent to thirty percent of PD, however, they are easy to be miss diagnosed or misdiagnosed because of the delitescent clinical manifestation. Almost all kinds of PD have symptom of rigidity. Especially in the advanced stage of disease, rigidity, bradykinesia, hypokinesia and dyskinesia originated from treatment of Madopar are the main causes of disability and lethal complication. Incidence of PD is increasing as the aging of population. The objectives of this research is to preliminarily evaluate the clinical efficacy of PD NO.1 (experimental prescription of my tutor-Professor Luo) on PD. This research may provide basis for the Traditional Chinese Medical (TCM) recognition of PD ( hypokinesia type and rigid type ), for summarizing and generalizing TCM therapy on PD ( hypokinesia type and rigid type ) , and for exploitation of new drugs.Methods: This research is a prospective randomized controlled trial. All the forty-one qualified patients come from PD special out-patient or hospital ward of Guandong Hospital of Traditional Chinese Medicine. These patients were grouped randomly into two groups: Twenty-two in Group A , nineteen in Group B. Therapy of Group A was: Decoction of PD NO. 1, PO, one dose QD, together with Madopar 250mg in the mornings 125mg in the noon, 125mg in the evening, PO; therapy of Group B was only taking Madopar orally, the dose was as same as Group A. Observing cycle of the two groups were both three months. SPSS 11.0 software was used to handle datum. T-test was used to handle quantitative datum and rank sum test was used to handle categorical datum. Results:Prior treatment, gender, age, course of disease, H-Y grading of pathogenic condition and UPDER score, medication of the two groups had no statistical difference(p>0. 05). After treatment, in Group A, seven cases had no effect or had aggravation, six cases had mild amelioration, eight cases had amelioration and one case had obvious amelioration. The total effective...