Effect Of IL-5,IL-8 And Clinical Research On Efficacy Of Acute Bronchial Asthma With Shemazhichuan Decoction

Bronchial Asthma(BA) is one of the most common disorders encountered in clinical medicine in both children and adults. It is often considered as a refractory disease associated with chronic bronnic bronchial inflammation whose syndrome are recurrent gasp, dyspnea,stuff chest or cough, then even orthopnea. There are approximately 20 million populations in our country and 150 million ones in the whole world affected by this disease. It severely influences patients on health and life. The incidence of BA shows the ascendant trend these years from the epidemiology. So, WHO, governments and clinical doctors are paying more and more attentions to preventing and curing BA.The objective of this paper is to observe the efficacy and safety of Shemazhichuan Decoction and try to investigate its possible mechanism.1. Review of the literatureThe paper goes over a lot of articles about asthma which are written or published by famous ancient, modern and foreign doctors. Ancient Traditional Chinese Medicine(TCM) doctors had their own viewpoints on asthma a long time ago. They set up their ideas on etiology and pathogenesis including theory of asthma due to retention of phlegm-fluid, theory of asthma due to weakness of self Zheng qi, theory of asthma due to retention of phlegm, theory of asthma due to exopathy. And they also set up many kinds of therapies including resolve the phlegm, support Zheng qi , support Zheng qi and Expel Xie qi simutaneously. Meanwhile they had created a lot of effective formulae which we called "classical Formulae" such as Xiaoqinglong Decoction, Sheganmahuang Decoction.Modern TCM doctors inherited from ancient ones and developed a series of new theories. They considered theory of outbreak time due to phlegm and blood stasis, stagnation of phlegm, phlegm and qi stasis, cause by phlegm and wind, cole phlegm stasis, hot phlegm stasis, qi stasis, qi up, cause by stomach and kidney. They considered theory of relaxed time due to weakness of spleen, weakness of spleen and lung, weakness of qi of lung etc. At the same time, integrative medicine also developed a series of new thories, for example theory of Three Levels, fattiness metabolizability turbulence etc. There are many methods to cure the disease, which used mostare these methods:the method of resolving the phlegm and setting down the reverse flow of qi, the method of expelling the wind and resolving the convultion, the method of quichening the blood and removing the stagnation, the method to adjust qi of lung and set down the qi, the method to manage the qi and resolve phlegm etc. What' s more, some other methods such as acupuncture therapy, single Chinese herbal medicine monomer and atomization and inhalation therapy and give medicament through recta are also proved to be effective. Foreign doctors whoever in ancient time or modern time also had rich experience about TCM therapies of asthma.According to the clinical experiences in our respiratory department this paper regards cold phlegm stagnating in the lung and phelgm blocking airway as acceptable etiology and pathogenesis.So we applied method of expelling the wind and resolving phlegm and method of resolving the convultion and setting down the reverse flow of qi. And we got quite a satisfactory result.With the development of the clinical research, modern medicine has realized that Asthma is a chronic inflammation disorder of the airways in which many cells and cellular elements play a role. Chronic inflammation causes an associated increase in airway hyperresponsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness, and coughing,particularly at night or in the early morning. These episodes are usually associated with widespread but variable airflow obstruction that is often reversible either spontaneously or with treatment. There are some mechanisms in newly studies including the mechanism of inflammatory responses, Thl/Th2 immunological responses and neuroregulation. The antiinflammatory therapy is the primary principle of treatment. Glucocorticoid hormone is the first choice. But a lot of side effects restrict it being used abroad.2.The clinical study30 patients with acute BA, mild or moderate degree, were randomly divided into two groups:1. the therapeutic group with Shemazhichuan Decoctionand and aminophylline;2.the control group with aminophylline. Observe the changes of the main symptoms, physical signs, pulmonary function (mainly FEV1, FVC , FEV1/FVC%, PEF ), peripheral-blood EOS counting, total IgE level and IL-5, IL-8 in the blood serum .The results show that: the control & excellent effective rates and the total effective rate of the therapeutic group were 80% and 93. 33% respectively, while 73.33% and 93.33% of the control group.The changes of the main symptoms, physical signs, pulmonary function (mainly FEVl, FVC, FEV1/FVC%, PEF ), peripheral-blood EOS counting, total IgE level and IL-5, IL-8 in the blood serum in both groups are obviously improved. This indicates that Shemazhichuan Decoctionare effective in treating acute outbreak of BA.While there's no remarkable difference between two...