The Association Between Serum Insulin And Serum Lipid Substances And Breast Cancer

Objective To investigate the correlation between seruminsulin , lipid expression substances and breast cancer .Method From January to August 2002, blood samples were collected from 90 patients with breast cancer , 40 case patients with breast benign disease and 100 healthy control subjects in Shanxi Province People Hospital. Serum insulin was measured by ELISA, serum leptin was measured by radioimmunoassay (RIA) and serum lipid substances were measured by Biochemistry Auto - machine. Results (l)The serum insulin , leptin and TG concentration were significantly higher , but the HDL level was significantly lower in breast cancer group than in the groups of breast benign disease and healthy control (P<0. 01, respectively). (2)There was no statistically significant difference between postmenopausal and premenopausal women in patients with breast cancer and breast benign disease .IV(P>0.05) ;(3) There was no statistically significant difference in serum insulin level between positive lymphol node breast cancer and negative lymphol node breast cancer(P=0. 642) . (4)The relative risk (RR) of serum insulin level and body mass index (BMI)in breast cancer group was 0. 164(P>0.05) .The increased serum insulin level was independent of diet and other known risk factors for breast cancer. (4) Multiple logistic regression analyses observed a statistically significant association between serum insulin , leptinN TG and HDL levels and breast cancer incident. OR 1. 110(95%CI: 1.017-1. 209), 1.140 (95%CI: 1.076-1.209) ,1.879 (95%CI: 1.148-3.076), 0.035 (95%CI: 0. 007-0. 162), respectively. Conclusion The increased serum insulin , leptin and TG levels may be the risk factors of breast cancer. The increased serum HDL level maybe the protective factors of breast cancer incident.