The Association Between Serum Leptin And Serum Lipid Substances And Breast Cancer

Objective To investigate the association between serum leptin concentration , lipid substances , body mass index(BMI) and breast cancer . Method From January 2002 to August 2002, blood samples were collected from 90 case patients with breast cancer , 30 case patients with breast benign disease selected from Shanxi Tumor Hospital ,103 case healthy control subjects were from the same areas as the patient's Epidemiologic information and anthropometric measurements were collected in personal interviews. Serum leptin were measured by radioimmunoassay (RIA) and serum lipid substanceswere measured by Biochemistry Auto - machine. Results (1) There was no statistically significant difference between postmenopausal and premenopausal women in patients with breast cancer patients and breast benign disease patients . (P>0.05) ; (2) The serum leptin concentration and BMI in breast cancer group were significantly higher than in the groups of breast benign disease and healthy control (P<0. 01, respectively). But there was no difference between breast benign disease and healthy control (P>0.05). (3) There was a statistically significant that higher APOA1 and lower HDL were in breast cancer patients comparing with breast benign disease and healthy control (P<0.001, respectively). (4) Multiple logistic regression analyses observed a statistically significant association between serum leptin, TG and HDL-C levels and breast cancer incident. (ORLePtin=1. 14, 95% confidenceinterval [CI]: 1.076 to 1.210 ; ORApOAI =5.726, 95% confidence interval [CI]: 1.238 to 26. 480 and ORHDL=0. 035, 95% confidence interval [CI]: 0.007 to 0.162,respectively). Conclusion Our results suggest that the increased serum leptin levels and APOA1 may be the risk factors and HDL-C may be the protector of breast cancer incidence. The serum leptin may become a clinic marker of breast cancer. The BMI was significantly higher in breast cancer group, and was positively correlation with leptin level. Our study suggest that it is a effective method to prevent the incidence of the breast cancer by controlling weight, decreasing the serum leptin and TG level. But further research is needed to confirm these findings and to clarify the underlying mechanisms involved.