Clinical Study On The Relationship Between The Occurrence Of Breast Cancer And Its Pathological Characteristics And Serum Lipid Level

Objective : By comparing the difference in serum lipid level between breast cancer and other breast diseases,the aim is to understand their differences in breast diseases and different types of breast cancer,and further explore the relationship between the occurrence of breast cancer and its pathological characteristics and serum lipid level,and provide new ideas for the prevention and adjuvant treatment of breast cancer.Methods : We gathered 200 cases of invasive breast cancer patients who underwent breast surgery in our hospital,200 patients with benign breast disease who were treated in our department at the same time and 87 cases of non-lactating mastitis patients from September 2016 to September 2018.We recorded the lipid level of three groups of patients and compared the indicators.A subgroup analysis of patients in the breast cancer group was conducted to explore the relationship between menopausal status,lymph node metastasis,hormone receptor status,molecular typing and serum lipid level in breast cancer patients.The collected data were analyzed by EXCEL software,and the difference between the lipid level of each component was examined by t-TEST.Result:The serum lipid level of breast cancer group,benign breast tumor group and non-lactating mastitis group were compared.The results showed that the serum lipid level of breast cancer patients were the highest in different age groups,and the difference was statistically significant.The L/T in serum lipid of patients with breast cancer and non-lactation mastitis group was higher than that of benign breast disease group,H/T and H/L were lower than those of benign breast tumor group(P<0.05),while there was no significant difference in L/T,H/T and H/L between non-lactating mastitis group and breast cancer group.This suggested that the levels of L/T,H/T and H/L in serum lipids of breast cancer patients are similar to those of non-lactating mastitis,which are different from patients with benign breast tumors.The serum lipid of the breast cancer group showed higher levels of TC,LDL-C,L/T and lower levels of H/T and H/L than those with benign breast tumors(P<0.05),suggesting that breast cancer may be factors affecting TC and LDL-C.According to the analysis of menopausal status,the TC,LDL-C and L/T of postmenopausal patients in breastcancer group were higher than those in benign breast tumor group,and H/T and H/L were lower than those in benign breast tumor group(P< 0.05),there was no significant difference in serum lipid level between the two groups before menopause,suggesting that menopausal status may be the influencing factor of high TC and LDLC in serum lipid of breast cancer patients.The subgroup analysis of serum lipid level in patients with breast cancer showed that TC was lower in Luminal group than in non-Luminal group.The difference was statistically significant.In the Luminal group,TC and LDL-C were lower than those in non-Luminal group,the difference was statistically significant(P < 0.05),suggesting that hormone receptor expression may affect TC levels in serum lipid.There were no significant differences in serum lipid level between premenopausal and non-Luminal premenopausal patients,HER-2positive and HER-2 negative patients,axillary lymph node metastasis and axillary lymph node metastasis.Conclusion: There may be an interaction between breast cancer and serum lipid level.The increase of TC and LDL-C in serum lipids may be a risk factor for breast cancer,while breast cancer and its menopausal status,hormone receptor expression status were related to the changes of TC,LDL-C,L/T,H/T and H/L in serum lipids.