| Cerebrovascular disorder, which is called Nao-Zhu-Zhong or Zhong-Feng in Traditional Chinese Medicine, is a common disease that affects seriously human's health. Its incidence rate, prevalence rate and death rate are in very high levels. Cerebrovascular disorder, cancer and cardiovascular disease are most major diseases that cause human death in current world.It were find that, after the blood supply is decreased and stopped, although there are some necrosis in the central zone, but there are still ion-balance and integrative structure in a some time. If the blood supply can be recovered in time, it is possible that those organizes are recovered. It shows that the Cerebrovascular disease is can be controlled if we make some positive effort to high blood pressure, atherosclerosis and other factor. Treatments for cerebral arterial thrombosis can vary according to particular case. Cerebral edema can be controlled with dehydration; we can use hemangiectasia drug, calcium antagonists, and platelet aggregation inhibitors to avoid recurrent cerebral infarction and decease thewe possibility of vascular dementia. In earliest period of disease (in six hours), we can use thrombolytics; in early period (in 72 hours), we can use Calcium antagonists, vasodilators, dehydrator, radical scavenger and etc. In addition, we should plane our treatment according the origin of a disease; we can adopt special treatment to deal with change of blood vessel, blood dynamics (including blood pressure's decrease and cardiac function) and etc. But few of those medicines have the overall effects on those different origins of a disease. A lot of them are only for a particular case. Therefore combined medicines are used in clinical treatments.Since Chinese medicine had complex ingredients and a lot of receptor, it became a hotspot in the research and development of medicine for cerebral apoplexy. Hong Hua Tong Luo injection is a kind of complex injection of Tradition Chinese medicine. It was developed according to base requirement of 2nd class of tradition Chinese medicine. The major pharmacodynamics research work had been completed. A good effect was shown. The Hong Hua Tong Luo's pharmacodynamics research and mechanism had been done basing on following aspects:1. Hong Hua Tong Luo's effect to Rat's brain ischemia injuriesThe study in three test groups( high dose, middle dose, lower dose) shown that Hong Hua Tong Luo can notably improve the rat's cerebral apoplexy caused, which is result of thrombus in medium-sized artery caused by iron sesquichloride, after 72 hours. There are significant discrepancies ( P < 0.05, P < 0.01, P < 0.001) in comparing with model group. Hong Hua Tong Luo can effectively decrease degree of brain ischemia injuries, especially in the group, which was in dose 120mg/Kg. Only half of animals were found that had evident regional necrosis in cerebral cortex, and there were not neuron injuries in other region and seahorse region.Hong Hua Tong Luo can notably improve the cerebral edema, which is in the high-dose group, after 72 hours. Comparing with the contrast group, there are evident differences (P<0.05, P<0.01). In addition, it can decrease the level of evans blue in brain also. The difference (P <0.01) is significant. The study in high-dose group shown that Hong Hua Tong Luo can increase the time, which was spent to form thrombus. We can find the tendency in other group, but there are not notable differences with contrast group. Stimulated by ice water, the blood clot was found in rat, which is be injected with Adr. It is easy to form thrombus (P<0.01, P<0.001). Hong Hua Tong Luo can refrain the forming of thrombus, the effect is evident comparing with contrast group.In addition, Hong Hua Tong Luo can refrain the abnormal change in blood flow, it can decrease the blood viscosity (P<0.05, P<0.01).2. Study of mechanism of improvement in rat's Rat's brain ischemia injuriesIn there groups, Hong Hua Tong Luo can notable decrease the possibility of platelet adhesiveness, it is a...
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