| Objective(1) Exploring the major risk factors and etiologic model of hepatocellular carcinoma by clinical epidemiological study, in order to provide the scientific basis for preventive measures.(2) investigating the risk degree of different oncogenes and anti-oncogenes on hepatocellular carcinoma(HCC)'s occurrence, progress, mouse out theoretics basis on gene level for hepatocellular carcinomaMaterials and Method(1) Alimentary tract tumors were formed the cohort set of this study, all were hospitalized in Wuhan university Zhongnan Hospital or Wuhan Army Hospital in 1st January, 2000 to 31st July, 2003. Eliminating secondary liver cancer, 313 hepatocellular carcinomas were formed the case group of this study. Diagnosis basis is B ultrasonic wave or CT and index of laboratory, for example, AFP, ALT, AST and so on, combining with clinical symptom, some of cases were done pathological Biopsy. Two methods were used to select controls in this study. Firstly, for each case, one other alimentary tract tumors was randomly selected from the cohort set as control, resulting a final control group of 313 individuals; then, for each case matched with sex, age, profession and education, 103controls (1 '. 1) were selected as controls.The study was based on the questionnaire by graduate student Public Health School Wuhan University. The study content composed of general characteristics, personal habits and history of viral hepatitis, family history of tumor and the habit of dietary, including sex, age, profession, education, dietary habit, alcohol consumption, cigarette smoking and drinking tea and so on. The index of laboratory include HBsAg, HBsAb, HbeAg, HBeAb, HbcAg, HBcAb and HCV-Ab by Enzyme-linked immunoadsordent assay (ELISA).SPSS and SAS were used to analyze data in this study. Univariate analysis was the firstanalyzing step for both sample 1 and sample 2. Then, variables showing associations with the risk of Hepatocellular carcinoma at P<0.10 level were further tested in stepwise non-conditional and conditional Logistic regression models for sample 1 and sample 2, respectively. The final model consisted of those variables showing a significant level at P<0.05. OR value and its 95% CI were calculated for these factors.(2) Search documents by computer, handiwork and retrospective and undertake quality assessment to eliminate articles which is repeatly reported, ropy , not integrated or little information according to Lichtenstein criterion. Result(1) In the sample 1, age was closely associated with HCC, the result showed that the incidence of HCC increased as age increased, it reached the max at the age of 40 to 50 years old, then drop down as age increased. The result showed that the average diagnosed age of HCC was 50.68?2.807, significantly younger than that of controls, which was 57.54?3.652 years old (P<0.001).In the univariate analysis of sample 1, compared with female, the OR value of male for HCC was 4.9968. In different profession and education, it suggested that fatalness for HCC with people in high-tech was high, its OR values were 1.163, 1.273, respectively. After transforming the profession and blood type into dunny variable, it was suggested that peasan, technology personnel and A blood type were correlation with HCC, which OR values were 1.613,0.520, 1.867, respectively.After controlling the confounding factor of age, the OR value for tobacco smoking, alcohol consumption were 2.836, 2.886; meanwhile, there was interaction between tobacco smoking and alcohol consumption, the OR value of HCC for who was both cigarette smokers and alcohol drinker compared with who was neither smoke nor drink was 3.268; the OR value of HCC for cigarette smokers compared with who was neither smoke nor drink after adjustment for alcohol consumption was 2.142; the OR value of HCC for alcohol drinker compared with who was neither smoke nor drink after adjustment for cigarette smoking was 3.046; individuals whose age was less than 19 years old to smoking ordrinking firstly had a OR of 4.691, 3.870 compar...
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