Expression Of IL-13 And Relationship With Airway Hyperresponsiveness In Patients With Asthma And COPD

Objective To explore the expression of interleukin-13 and relationship with airway hyperresponsiveness in patients with Asthma and chronic obstructive pulmonary disease. Methods The study group included 30 cases in remission stage and active attack separately, control group had 20 cases. The venous blood was drawn, and the IL-13 level from cultured peripheral blood mononuclear cell(PBMC) supernatant and serum were detected by ELISA methods. At the same time FEV1% FVC% isoFEF25-75%% were measured. The results of determination were analyzed statistically. Result The serum and PBMC-induced IL-13 and FEV1% FVC% isoFEF25~75% % from asthmatic patients in active attack was higher than that in remission stage (P<0. 01) ;Both were higher than that of normal control group (P<0. 01) . linear correlation analysis shows that The serum and PBMC-induced IL-13 are positively correlated to the FEV1% , in remission stage separately , r=0. 862 and r=0. 928 (P<0. 01) , and in active attack, r=0. 708 and r= 0.866, (P<0. 01) ; The serum and PBMC-induced IL-13 and FEV1%, FVC%, isoFEF25~75%% from COPD patients in active attack was higher than that in remission stage (P<0. 01) , Both were higher than that of normal control group (P<0.01) . linear correlation analysis shows that The serum and PBMC-induced IL-13 are positively correlated to the FEV1% separately , r=0. 443, p<0. 05; r=0. 647, P<0. 01 in the active attack stage . The serum and PBMC-induced IL-13 are no correlated to the FEV1% in remission stage separately, r=0. 347 and r=0. 331, P>0. 05. Conclusion the results indicated thatIL-13 can play an important role in pathology with asthma and chronic obstructive pulmonary disease, which may be one of reasons formulating airway hyperresponsibility. The study suggested that IL-13 level may be a helpful index for monitoring and instructing the treatment in asthma and COPD, which will have some clinical meaning.